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Barbiturates may be habit forming. Tolerance and psychological and physical dependence may occur with continuing use.Slow IV injection is essential, and patients should be carefully observed during administration. This requires that blood pressure, respiration, and cardiac function be maintained, vital signs be recorded, and equipment for resuscitation and artificial ventilation be available. The rate of IV injection should not exceed 50 mg/min for pentobarbital sodium.
Collaborate with other healthcare professionals to ensure coordinated and comprehensive care for patients receiving pentobarbital therapy.
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The use of barbiturates carries with it an associated risk of psychological and/or physical dependence. The patient should be warned against increasing the parte of the drug without consulting a physician.
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Maintenance of an adequate airway, with assisted respiration and oxygen administration as necessary.
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The effect of the resultant decreased blood levels of griseofulvin on therapeutic response has not been established. However, it would be preferable to avoid concomitant administration of these drugs.
Phenobarbital has been shown to shorten the half-life of doxycycline for as long as 2 weeks after barbiturate therapy is discontinued. This mechanism is probably through the induction of hepatic microsomal enzymes that metabolize the antibiotic.
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